You: Convert lisinopril 40 mg to losartan
Answer
| Starting Drug | Starting Dose | → | Target Drug | Equivalent Dose |
|---|---|---|---|---|
| lisinopril | 40mg | → | losartan | 100mg |
| Quick Answer: Lisinopril 40mg is approximately equivalent to Losartan 100mg. |
Key Clinical Considerations
- Losartan has a shorter half-life than lisinopril (2 hours vs. 12 hours), so a twice-daily dosing regimen for losartan (e.g. 50mg twice daily) may be considered to achieve more consistent 24-hour blood pressure control.
- There is a relative contraindication to ARBs if a patient has a history of angioedema with ACE inhibitors, though the risk is lower with ARBs.
Monitoring Requirements
- Monitor blood pressure closely after conversion.
- Monitor serum potassium and renal function within a few weeks of initiating the new medication.
Important Notes
- This conversion is based on typical dosing and equivalency ratios. Individual patient response may vary.
- Ensure the patient is not pregnant or planning to become pregnant before initiating losartan, as both ACE inhibitors and ARBs are contraindicated in pregnancy. Source: ACE Inhibitor to ARB Bidirectional Conversion Guide (Version 2.0, December 2024)
Source: ACE Inhibitor to ARB Bidirectional Conversion Guide (Version 2.0, December 2024). This guide is based on clinical practice guidelines, pharmacokinetic studies, and cardiovascular outcome trials.